Why test for fFN?
Determining who is really at risk for preterm birth can be a major challenge. Fetal fibronectin (fFN) testing can help rule out 80% of patients presenting with symptoms of preterm labor.1
Fetal fibronectin is an adhesive glycoprotein “glue” at the maternal-fetal interface and is a common biomarker for all 4 mechanisms of preterm birth.1,2 It is indicated for singleton and twin pregnancies.1
Gestational window for the fetal fibronectin test
- Women with symptoms of PTL from 240 – 346 weeks gestation
- Asymptomatic women from 220 – 306 weeks gestation
fFN test advantages1
- Result is objective, not subjective
- Reliably high NPV for both ≤ 7 and 14 days
- ~80% of patients will receive a negative result
- Can be used on both singleton and twin pregnancies
- Results <30 minutes after test initiation
Improved sPTB prediction with cervical length + fFN
Using fFN testing, in addition to measuring cervical length with transvaginal ultrasound (TVUS), increases the predictivity of cervical length results by as much as 50%.4
Risk of sPTB in patients with symptoms of preterm labor:
fFN testing can help optimize resources
Standardizing preterm labor evaluations reduces unnecessary admissions and interventions.5 Data shows that adding fFN to PTL triage reduces length of stay. In one study, adding fFN testing reduced the average hospital stay from 5.2 days to 0.6 days.6
Adding fFN testing dramatically reduced unnecessary admissions
Case Study 1: Brigham and Women’s Hospital
At the Brigham and Women’s Hospital the introduction of fFN in PTL triage led to a decrease in unnecessary admissions.7
Case Study 2: Mayo Clinic
The Mayo Clinic reduced the rate of hospital admissions by 56% and reduced the average length of stay by 4.5 days.6
International fFN testing
Outside of the United States there are two types of fFN tests available.
Quantitative fFN Testing
The Quantitative fFN test provides a patient’s quantitative level of fFN on a scale of 0 ng/mL to 500 ng/mL, unlike the U.S. Rapid fFN® test which provides a positive or negative result based on a 50 ng/mL cut-off.
Visit the U.K. fFN website for more information.
QuikCheck™ fFN Testing
The QuikCheck fFN test is an alternative visual-read fFN test for non-U.S. hospitals in triage locations where using the Rapid fFN® analyzer-read test is not possible.
Contact us for more information about the Rapid fFN® test.