Why test for fFN?

Determining who is really at risk for preterm birth can be a challenge. Fetal fibronectin (fFN)
testing can help rule out 80% of patients presenting with symptoms of preterm labor.

INTERPRET RESULTS

Qual Glue Upside Down Baby 30week

fFN is the special glue between mother and baby

Fetal fibronectin (fFN) acts as an adhesive glycoprotein at the maternal-fetal interface and is a common biomarker for all four mechanisms of preterm birth. It is indicated for singleton and twin pregnancies.1

Gestational window for the fetal fibronectin test

  • Women with symptoms of PTL from 24 – 34 weeks gestation
  • Asymptomatic women from 22 – 30 weeks gestation

Negative Test Icon 1

fFN test advantages1

  • Result is objective, not subjective
  • Reliably high NPV for both ≤ 7 or ≤ 14 days
  • ~80% of patients will receive a negative result
  • Can be used on both singleton and twin pregnancies
  • Results <30 minutes after test initiation
  • Sample can be collected for FREE
  • Sample is valid for up to 8 hours at room temperature or 3 days refrigerated
  • A negative result is valid even if a patient has had sex in the previous 24 hours
  • The Rapid fFN test has high negative predictive value of >99% for ruling out imminent preterm birth1,2
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Improve sPTB risk assessment with cervical length + fFN

Using fFN testing, in addition to measuring cervical length with transvaginal ultrasound (TVUS),
increases the predictivity of cervical length results by as much as 50%.3

Risk of sPTB in patients with symptoms of preterm labor:
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fFN testing can help optimize resources

Standardizing preterm labor evaluations may reduce unnecessary admissions and interventions.4 Data shows that adding fFN to PTL triage may reduce length of stay. In one study, adding fFN testing reduced the average hospital stay from 5.2 days to 0.6 days.5

Adding fFN testing dramatically reduced unnecessary admissions
ffn testing case study 1

Case Study 1: Brigham and Women’s Hospital

At the Brigham and Women’s Hospital the introduction of fFN in PTL triage led to a decrease in unnecessary admissions.5

ffn testing case-study

Case Study 2: Mayo Clinic

The Mayo Clinic reduced the rate of hospital admissions by 56% and reduced the average length of stay by 4.5 days.6

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Assess preterm birth risk with the Rapid fFN test

Contact us for more information about Rapid fFN®.

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Assess preterm birth risk with the Rapid fFN test

Contact us for more information about Rapid fFN® test.

CONTACT US

References

1. Rapid fFN for the TLiIQ System [package insert]. AW-24196-001, Rev. 001, San Diego, CA: Hologic, Inc.; 2020 2. Lockwood CJ, Kuczynski E. Risk stratification and pathological mechanisms in preterm delivery. Paediatr Perinat Epidemiol. 2001;15(suppl 2):78-89. 3. R Gomez, et al. Cervicovaginal fibronectin improves the prediction of preterm delivery based on sonographic cervical length in patients with preterm uterine contractions and intact membranes. AJOG 2005;192:350-359. 4. Behrman RE, et al, eds. Preterm Birth: Causes, Consequences and Prevention. Institute of Medicine (US) Committee on Understanding Premature Birth and Assuring Healthy Outcomes. Washington, DC: National Academies Press; 2007. 5. Iyer S, McElrath T, Jarolim P, et al. The association of fFN testing on hospital admissions for preterm labor. Open J Obstet Gyn. 2013;3(1):126-129. 6. Rose CH, McWeeney DT, Brost BC, et al. Cost-effective standardization of preterm labor evaluation. Am J Obset Gynecol. 2010;203(3):250. e1-5. 6. Iyer S, McElrath T, Jarolim P, et al. The association of fFN testing on hospital admissions for preterm labor. Open J Obstet Gyn. 2013;3(1):126-129.