Why Fetal Fibronectin (fFN) Predicts Preterm Birth Risk

Fetal fibronectin (fFN) is the single common biochemical marker for all 4 mechanisms of preterm birth: activation of the maternal/fetal hypothalamic-pituitary-adrenal (HPA) axis, inflammation, decidual hemorrhage, and pathological uterine distention. It acts as an adhesive glycoprotein at the maternal-fetal interface. Its premature presence in vaginal secretions is a direct biochemical predictor of preterm birth risk.1

Fetal fibronectin is the “glue” at the maternal-fetal interface.1

Fetal fibronectin is the single common biomarker for all 4 mechanisms of preterm birth1

Adapted from i. Lockwood CJ, Kuczynski E. Risk stratification and pathological mechanisms in preterm delivery. Paediatr Perinat Epidemiol. 2001;15(suppl 2):78-89.

Reference

  1. Lockwood CJ, Kuczynski E. Risk stratification and pathological mechanisms in preterm delivery. Paediatr Perinat Epidemiol. 2001;15(suppl 2):78-89.

 

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